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After years of looking for Mr. Right, Charlotte `Charlie' Cantilini finally finds the man of her dreams, Kevin Fields, only to discover that his mother, Viola, is the woman of her nightmares. A recently fired news anchor who is afraid she will lose her son the way she has just lost her career, Viola determines to scare off her son's new fiancé by becoming the world's worst mother-in-law. While Viola's long-time assistant Ruby does her best to help Viola execute her crazy schemes, Charlie decides to fight back and the gloves come off as the two women battle it out to see just who is the alpha-female.
A doting, overly-possessive mother (Jane Fonda) fresh from a mental breakdown after she was replaced on her TV talk show re-enters her son's life just as he (Michael Vartan) decides to get engaged to a free spirited, multi-talented woman who works as a dog-walker & temp at a doctor's office . Immediately seeing the woman (Jennifer Lopez) as a threat, she puts on a good face in front of her son but immediately starts plotting against her. However, two can play that game and the war is on. In the middle of the mess is the mother's assistant (Wanda Sykes), who is loyal to her boss but has been with her long enough to not take any of her guff.
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