| Jessica Alba | Morley Clarkson |
| Kathy Bates | Susan |
| Jessica Biel | Kara Monahan |
| Bradley Cooper | Holden |
| Eric Dane | Sean Jackson |
| Patrick Dempsey | Dr. Harrison Copeland |
| Hector Elizondo | Edgar |
| Jamie Foxx | Kelvin Moore |
| Jennifer Garner | Julia Fitzpatrick |
| Topher Grace | Jason |
| Anne Hathaway | Liz |
| Carter Jenkins | Alex |
| Ashton Kutcher | Reed Bennett |
| Queen Latifah | Paula Thomas |
| Taylor Lautner | Willy |
| George Lopez | Alphonso |
| Shirley MacLaine | Estelle |
| Emma Roberts | Grace |
| Julia Roberts | Captain Kate Hazeltine |
| Bryce Robinson | Edison |
| Taylor Swift | Felicia |
| Matthew Walker | Greg Gilkins |
| Larry Miller | Oversized Baggage Agent |
| Beth Kennedy | Mrs. Claudia Smart |
| Katherine LaNasa | Pamela Copeland |
| Kristen Schaal | Ms. Gilroy |
| Erin Matthews | Flight Attendant |
| Christine Lakin | Heather |
| Lauren Reeder | Hotel Clerk Michelle |
| Joey Sorge | Amos |
| Julia Springer | Olivia Copeland |
| Alec Nemser | Charlie |
| Kathleen Marshall | Siena Bouquet Nikki |
| Rick Batalla | Michael |
| Anna Kulinova | Bulgarian Girl |
| Cassie Rowell | Coffee Barista |
| Faline England | Flower Shop Customer #1 |
| Jim McCann | Flower Shop Customer #2 |
| Shea Curry | Indian Restaurant Friend Elise |
| Alexis Peters | Friend Dana |
| Wedil David | Rani's Mom Rehka |
| Natalie Timmermans | Indian Bride |
| Jennifer Leigh Warren | Party Singer |
| Scott Crumly | Indian Restaurant Valet |
| Jonathan Morgan Heit | School / Soccer Tough Franklin |
| Megan Suri | Rani |
| Brooklynn Proulx | Madison |
| Karolinah Villarreal | Gwen |
| Angelo Salvatore Restaino | Alex's Friend Gideon |
| Scott Marshall | Mr. Schwabbe |
| Kelly Flynn | Referee |
| Sam Marshall | Soccer Son |
| Mandy Medlin | Teacher |
| Larrs Jackson | Airport Chauffer Redmond |
| Cleo King | TAS Supervisor Daisy Bell |
| Corena Chase | TSA Security Officer |
| Justin Michael Dival | TAS Security Guard |
| Heidi Brucker | Southwest Gate Agent |
| Lily Marshall-Fricker | Lily |
| Kamilla Bjorlin | Sherry Donaldson |
| Anna A. White | Weather Girl (as Anna Aimee White) |
| Stefanie Sherk | Stage Manager |
| Marty Nadler | Cameraman #1 |
| Scott Sener | Cameraman #2 |
| Colin Owens | Male Anchor |
| Calvin Jung | Flower Mart Simon |
| Serena Poon | Chinese Vendor |
| Kazumi Nakamura | Japanese Vendor |
| Gwenda Perez | Spanish Vendor |
| Kiko Kiko | Dodger Grandmother |
| Joseph Leo Bwarie | Mailroom Danny |
| Robert Belushi | Mailroom Ted |
| Jaclyn Miller | ACM Receptionist |
| Joe Smith | ACM Restaurant Waiter |
| Katie Joy | ACM Outdoor Café Waitress |
| Lisa Roberts Gillan | Young Nurse |
| Barbara Marshall | Head Nurse |
| Stephanie Fabian | Candy Striper |
| Sandra Taylor | Beach Girl Candy |
| Sarah Lilly | Lady With Dog |
| Tony Scruggs | Beverly Wilshire Waiter |
| Roberta Valderrama | Angry Girlfriend |
| Cyrus Alexander | Cisco the Cheater |
| Peter Allen Vogt | Cupid |
| Paul Vogt | Shouting Sheldon |
| Bonnie Aarons | Strange Lady |
| Adreana Betan | Cemetery Ticket Vendor (as Adreana Gonzalez) |
| Matt Merchant | Loud Guy |
| Lisa Valenzuela | Loud Lady |
| Howard Storm | Louder Guy |
| Jennifer Amy | Bistro Gardens Waitress |
| Rance Howard | Bistro Gardens Diner |
| Travina Springer | Sign Language Interpreter |
| Tracy Reiner | French Photographer |
| Hannah Storm | ESPN Hannah Storm |
| Mike Greenberg | ESPN Radio Announcer #1 (voice) |
| Mike Golic | ESPN Radio Announcer #2 (voice) |
| Paul Williams | Romeo Midnight |
| Kristin Mellian | Bistro Gardens Waitress #2 |
| Nicole Abramson | Soccer Mom |
| Sterling Cooper | Roger |
| Norman Deesing | Celebrity Lookalike |
| Jerald Garner | Kara's Friend |
| Roger Groh | Box Office Manager |
| Melinda Haugh | Bistro Gardens Waitress #3 |
| Aramis Knight | (voice) |
| Rachael Lee | School girl on stairs |
| Kathryn Le | Connie |
| David Andrew Monahan | Dude 3 |
| Aaron Pushkar | Bistro Gardens Bartender |
| Gishel Rafael | |
| Gabriel Rydel-Jurgens | Jimmy the Wise Kid |
| Agnes-Nicole Winter | Theater Guest |
| Guilford Adams | Vista Movie Theatre Owner (uncredited) |
| Josh Driver | Angry Theatre Patron (uncredited) |
| Joe Mantegna | Angry driver (uncredited) |
| Garry Marshall | Musician (uncredited) |
