| Robert De Niro | Turk |
| Al Pacino | Rooster |
| 50 Cent | Spider (as Curtis Jackson) |
| Carla Gugino | Karen Corelli |
| John Leguizamo | Det. Simon Perez |
| Donnie Wahlberg | Det. Ted Riley |
| Brian Dennehy | Lieutenant Hingis |
| Trilby Glover | Jessica |
| Saidah Arrika Ekulona | Gwen Darvis (as Saidah Arrika) |
| Alan Rosenberg | Stein |
| Sterling K. Brown | Rogers |
| Barry Primus | Prosky |
| Melissa Leo | Cheryl Brooks |
| Alan Blumenfeld | Martin Baum |
| Oleg Taktarov | Yevgeny Mugalat |
| Shirly Brener | Natalya |
| Frank John Hughes | Charles Randall |
| Terry Serpico | Jon Van Luytens |
| Liza Colón-Zayas | Judge Angel Rodriguez |
| Malachy McCourt | Father Connell |
| Ajay Naidu | Dr. Chadrabar |
| Charles F. Krichman Jr. | Umpire |
| Rob Dyrdek | Rambo |
| Jamey Jasta | ESU Officer (as James Shanahan) |
| Fatso-Fasano | Stubby |
| Mia Barron | Jill Goldman |
| Andre B. Blake | Officer Jones (as Andrew Blake) |
| Chris Cenatiempo | Hispanic Man |
| John Cenatiempo | Joseph Cianci |
| Judy Del Giudice | Hostess |
| Bryan Chatlien | Ellis Lynde |
| Shalaya Patty Ford | Latasha |
| Shaun Kelvin | Cop #2 |
| Merritt Wever | Rape Victim |
| Les Chantery | Lawyer #2 |
| Katie Bukovsky | Coach |
| Tyrone Smith | Fly Ty |
| Jim Jones | Jim Jones |
| Darryl Pittman | 39 D / R Period |
| Margaret Head | Hot Girl |
| Katarzyna Wolejnio | Dancer |
| Edrick Browne | Stone Cold Killer (unconfirmed) |
| Brett Granstaff | Pokerface (unconfirmed) |
| Nicola Peltz | Lynn (unconfirmed) |
| Brian Stapf | Trager (unconfirmed) |
| Gail Bugeja | Club Goer / Kissing couple / Dancer (uncredited) |
| Tanisha Grant | Beautiful Waitress (uncredited) |
| Catie Lazarus | Sexy Girl (uncredited) |
| Kimberly Magness | Club dancer (uncredited) |
