| Jensen Ackles | Tom Hanniger |
| Jaime King | Sarah Palmer |
| Kerr Smith | Axel Palmer |
| Betsy Rue | Irene |
| Edi Gathegi | Deputy Martin |
| Tom Atkins | Burke |
| Kevin Tighe | Ben Foley |
| Megan Boone | Megan |
| Karen Baum | Deputy Ferris |
| Joy de la Paz | Rosa |
| Marc Macaulay | Riggs |
| Todd Farmer | Frank the Trucker |
| Jeff Hochendoner | Red |
| Bingo O'Malley | Officer Hinch |
| Liam Rhodes | Michael |
| Michael McKee | Jason (as Michael Roberts McKee) |
| Andrew Larson | Noah Palmer |
| Jarrod DiGiorgi | Doc Miller |
| Selene Luna | Selene |
| Cherie McClain | Commentator |
| Richard John Walters | Harry Warden / The Miner (as Rich Walters) |
| David Whalen | Bartender '08 |
| Denise Dal Vera | Nurse |
| Sam Nicotero | Bartender '98 |
| Tim Hartman | Eli Hanniger |
| Ruth Flaherty | Thelma |
| Annie Kitral | Desk Clerk |
| Jerry Johnston | Verne |
| Rita Gregory | Female Doctor |
| Brandi Engel | Teen Straggler |
| Mightie Louis Greenberg | Louis |
| Chris Carnel | The Miner |
| William Kania | Deputy Sheriff Murdock |
| Nicole Leigh Belle | Nurse from the past (uncredited) |
| Greg Hartle | Miner (uncredited) |
| John W. Iwanonkiw | Miner #7 (uncredited) |
| Zachary Mazefsky | TV News Cameraman (uncredited) |
| Benjamin Jeran McGinn | Rescue Miner (uncredited) |
| Beth Pedone | Rescue Miner (uncredited) |
| Kyle Quinn | Rescue miner (uncredited) |
| Nick Zezza | Rescue Miner (uncredited) |
