| Mark Wahlberg | Max Payne |
| Mila Kunis | Mona Sax |
| Beau Bridges | BB Hensley |
| Ludacris | Jim Bravura (as Chris 'Ludacris' Bridges) |
| Chris O'Donnell | Jason Colvin |
| Donal Logue | Alex Balder |
| Amaury Nolasco | Jack Lupino |
| Kate Burton | Nicole Horne |
| Olga Kurylenko | Natasha |
| Rothaford Gray | Joe Salle |
| Joel Gordon | Owen Green |
| Jamie Hector | Lincoln DeNeuf |
| Andrew Friedman | Trevor |
| Marianthi Evans | Michelle Payne |
| Nelly Furtado | Christa Balder |
| Jay Hunter | Pawnshop Man |
| Maxwell McCabe-Lokos | Doug |
| Kerr Hewitt | Kid |
| Stephen R. Hart | Tattoo Artist Owner |
| Martin Hindy | Demon (as Martin 'Mako' Hindy) |
| Herbert Johnson | Train Attendant |
| Philip Williams | Sergeant Adams |
| Warren Belle | Detective |
| Ted Atherton | Detective Shipman |
| Katie Odegaard | Jackie - Receptionist |
| Rico Simonini | Detective Sergeant Amerini |
| Pj Lazic | Junkie (as P.J. Lazic) |
| Brandon Carrera | Young Cop |
| Joshua Barilko | Ragna Rok Guard #1 |
| Conrad Pla | Captain Bowen |
| Larry Wheatley | Bartender |
| Janice Nguyen | Detective |
| Gouchy Boy | Doorman |
| Spike Adamson | Aesir Security Guard |
| Carlos Gonzalez-vlo | Man Who Gets Dosed With Drug |
| Lana Denis | Nude Person Making Out #1 |
| Barrington Bignall | Nude Person Making Out #2 |
| James Rogers | Nude Person Making Out #3 |
| Christina Jocic | Nude Person Making Out #4 |
| Noelle Gray | Nude Person Making Out #5 |
| Candice Hotchkiss | Nude Person Making Out #6 |
| Genadijs Dolganovs | Enforcer |
| Dale Yim | Beat Cop |
| Tig Fong | Lead Aesir Security Guard |
| Siobhan Murphy | Receptionist #2 |
| Sergei Nikolich | Anton |
| Kristina Falcomer | Girl at Party |
