| Adam Sandler | Lenny Feder |
| Kevin James | Eric Lamonsoff |
| Chris Rock | Kurt McKenzie |
| David Spade | Marcus Higgins |
| Rob Schneider | Rob Hilliard |
| Salma Hayek | Roxanne Chase-Feder (as Salma Hayek Pinault) |
| Maria Bello | Sally Lamonsoff |
| Maya Rudolph | Deanne McKenzie |
| Joyce Van Patten | Gloria |
| Ebony Jo-Ann | Mama Ronzoni |
| Di Quon | Rita |
| Steve Buscemi | Wiley |
| Colin Quinn | Dickie Bailey |
| Tim Meadows | Malcolm |
| Madison Riley | Jasmine Hilliard |
| Jamie Chung | Amber Hilliard |
| Ashley Loren | Bridget Hilliard |
| Jake Goldberg | Greg Feder |
| Cameron Boyce | Keithie Feder |
| Alexys Nycole Sanchez | Becky Feder |
| Ada-Nicole Sanger | Donna Lamonsoff |
| Frank Gingerich | Bean Lamonsoff |
| Morgan Gingerich | Bean Lamonsoff |
| Nadji Jeter | Andre McKenzie |
| China Anne McClain | Charlotte McKenzie |
| Dan Patrick | Norby the Ride Guy |
| Tim Herlihy | Pastor |
| Blake Clark | Bobby 'Buzzer' Ferdinando |
| Norm MacDonald | Geezer |
| Jonathan Loughran | Robideaux |
| Kevin Grady | Muzby |
| Richie Minervini | Tardio |
| Jackie Sandler | Tardio's Wife |
| Sadie Sandler | Tardio's Daughter |
| Sunny Sandler | Tardio's Daughter |
| Dennis Dugan | Referee |
| Lisa M. Francis | Bailey's Wife |
| Berkeley Holman | Bailey's Son |
| Michael Cavaleri | Young Lenny Feder |
| Andrew Bayard | Young Eric Lamonsoff |
| Jameel McGill | Young Kurt McKenzie |
| Kyle Brooks | Young Marcus Higgins |
| Joshua Matz | Young Rob Hilliard |
| J.D. Donaruma | Higgins' Father |
| Billy Concha | Scoreboard Guy |
| Alec Musser | Water Park Stud |
| Henriette Mantel | Waitress |
| Hunter Silva | Young Bailey |
| Christopher Borger | Young Malcolm |
| Connor Panzner | Young Robideaux |
| Jeremy Weaver | Young Muzby |
| Daniel Cohen | Young Tardio |
| Jonathan Crowley | Milk Kid |
| Jack Flaherty | |
| Charlie Alejandro | BBQ Guest (uncredited) |
| Cindi Alex | Mourner (uncredited) |
| Lilith Astaroth | Basketball Game Spectator (uncredited) |
| Katelyn Cahill | Restaurant Patron (uncredited) |
| Desiree April Connolly | One of Bailey's Friends' Wives (uncredited) |
| A.J. Coppola | Mourner (uncredited) |
| Diane Curran | 4th of July Cookout Guest (uncredited) |
| Christopher J. Davis | 4th of July Cookout Guest (uncredited) |
| Susan Farese | Funeral Mourner (uncredited) |
| Rebecca H. Fox | Extra (uncredited) |
| Sari Gagnon | Funeral Couple (uncredited) |
| Elle Hartman | Mom with Beehive Hairdo (uncredited) |
| Jack Hartman | Basketball Player #11 (uncredited) |
| Zoe Hartman | Girl at Game (uncredited) |
| Brina Healy | Basketball Game Fan (uncredited) |
| Matt Heron-Duranti | Funeral Couple (uncredited) |
| Frankie Imbergamo | Banquet Guest (uncredited) |
| Daniel Lowney | Baily's Crew (uncredited) |
| Dan Marshall | Mourner at Coach's Funeral (uncredited) |
| Megan Sacco | Basket Ball Mom (uncredited) |
| David L. Tamarin | Basketball Fan (uncredited) |
| Michael R. West | Water Wizz Employee (uncredited) |
