| Shia LaBeouf | Jerry Shaw |
| Michelle Monaghan | Rachel Holloman |
| Rosario Dawson | Zoe Perez |
| Michael Chiklis | Defense Secretary Callister |
| Anthony Mackie | Major William Bowman |
| Ethan Embry | Agent Toby Grant |
| Billy Bob Thornton | Agent Thomas Morgan |
| Anthony Azizi | Ranim Khalid |
| Cameron Boyce | Sam Holloman |
| Lynn Cohen | Mrs. Wierzbowski |
| Bill Smitrovich | Admiral Thompson |
| Charles Carroll | Mr. Miller |
| William Sadler | William Shaw |
| Deborah Strang | Jerry's Mom |
| Dariush Kashani | Sgt. Rourke (Translator) |
| Sean Kinney | JTAC Team Leader |
| Bob Morrisey | Director of Intelligence |
| J. Patrick McCormack | Pentagon General Council |
| Lorenzo Eduardo | Kwame |
| Madylin Sweeten | Becky |
| Jorge Pallo | Intel Officer #1 (as Jorge-Luis Pallo) |
| Gerald Downey | Console Tech |
| Tony Flores | Team Leader |
| Don Jeffcoat | FBI Agent (as Donnie Jeffcoat) |
| Craig J. Harris | Man on Train (as Craig Harris) |
| Jimmie Akins | Transit Cop on Train (as Jimmie L. Akins) |
| Eric Christian Olsen | Craig |
| Marc Singer | Explosives Developer |
| Michael Maize | Master Sergeant |
| Eiko Nijo | Masako (Tour Guide) |
| Peter Gail | PFPA Officer |
| Brad Grunberg | Circuit City Salesman |
| Cylk Cozart | Sectran Courier #1 |
| Manny Perry | Sectran Courier #2 |
| James Gohrick | Agent in Alley (as James C. Gohrick) |
| Josh Todd | Convenience Store Clerk |
| Colby French | Console Tech |
| Matt DeCaro | Stranger at Airport |
| Judith Moreland | Security Attendant at Airport |
| Rolando Molina | TSA Agent |
| Michael Kostroff | Jeweler |
| Nigel Gibbs | Callister Aide |
| Michael Daniel Cassady | White House Staffer |
| David Grant Wright | Secret Service Agent #1 |
| Jarod Einsohn | Reaper Control Tech |
| David Heckel | Squadron Commander |
| Jamie Martz | Northcom Control Tech |
| Greg Collins | Two Star General |
| McKay Stewart | F-16 Pilot |
| Terry Walters | Woman in Prius |
| Katija Pevec | Teenage Page |
| Chase Penny | Capitol Policeman #1 |
| Madison Mason | The President |
| Kevin Quinn | Pentagon Aide |
| Sebastian Tillinger | Pentagon Agent |
| Enver Gjokaj | Remote Pilot |
| Michael Potter | Doorkeeper |
| Webster Williams | Committee Head |
| Peggy Roeder | Forensics Agent #1 |
| Gary Houston | Forensics Agent #2 |
| Jonathan Chase | Suited Agent |
| Dean Cudworth | Capitol Policeman #2 |
| Lindsay Corinn Luecht | Girl on Train |
| Nicol Paone | Rachel's Friend #1 |
| Brittany Ishibashi | Rachel's Friend #2 |
| Stacey Scowley | Waitress |
| Stephen Simon | Secret Service Agent #2 |
| David Arakelyan | Ballochi Kid |
| Salah Salea | Funeral Chanter |
| Susan Jasmin Armon | Woman in Ballochi Village |
| Fahim Fazli | Al Kohei |
| Elijah Moreland | Guard at Library of Congress |
| David Rowden | Sectran Truck Driver |
| Brenda Goodbread | Speaker of the House |
| Caroline A. Jenks | Page |
| Roger Groh | Executive Aide to Callister |
| Lesley Stahl | Newscaster #1 |
| Leyna Nguyen | Newscaster #2 |
| Ralph Garman | Newscaster #3 |
| Rick Chambers | Newscaster #4 |
| Sharon Tay | Newscaster #5 |
| Kent Shocknek | Newscaster #6 |
| Brandon Caruso | Boy on Train |
| Daniel Caruso | Sam's School Band |
| Cyn Dulay | Train passenger (uncredited) |
