| Leonardo DiCaprio | Roger Ferris |
| Russell Crowe | Ed Hoffman |
| Mark Strong | Hani |
| Golshifteh Farahani | Aisha |
| Oscar Isaac | Bassam |
| Ali Suliman | Omar Sadiki |
| Alon Abutbul | Al-Saleem (as Alon Aboutboul) |
| Vince Colosimo | Skip |
| Simon McBurney | Garland |
| Mehdi Nebbou | Nizar |
| Michael Gaston | Holiday |
| Kais Nashif | Mustafa Karami |
| Jamil Khoury | Marwan (as Jameel Khoury) |
| Lubna Azabal | Aisha's Sister Cala |
| Ghali Benlafkih | Aisha's Nephew Rowley |
| Youssef Srondy | Aisha's Nephew Yousef |
| Ali Khalil | Zayed Ibishi |
| Giannina Facio | Hoffman's Wife |
| Chase Edmunds | Hoffman's Son Timmy |
| Morgan A. Vick | Hoffman's Daughter |
| Michael Stuhlbarg | Ferris' Attorney |
| Sherif Eltayeb | Executioner |
| David Ganly | Doctor at Qatar Military Base |
| Bijan Daneshmand | Amman Clinic Doctor |
| Houda Zbit | Hani's Wife |
| Omar Berdouni | Al-Saleem's Lieutenant |
| Richard De Mayo | Tony |
| Clara Khoury | Bassam's Wife |
| Abdu Rahim Kashmir | Safe House Jihadist |
| Sami Samir | Taxi Driver – Syrian Border |
| Xanthe Elbrick | Manchester News Reporter |
| Ali Alvi | Manchester Bomber #1 |
| Zef Balbona | Manchester Bomber #2 |
| Vedant Gokhale | Manchester Bomber #3 |
| Ran Nikfam | Amsterdam Bomber |
| Albert Twanmo | Japanese Tourist Husband with Camera |
| Ellie K. Wang | Japanese Tourist Wife |
| Allen Lidkey | Medic in Helicopter |
| Drif Said | Turkish Engineer / Explosives Expert |
| Zakaria Atifi | Al-Masri |
| William Meredith | Soldier in Qatar |
| Howard W. Overshown | Predator Room Captain #1 |
| Kathy K. Brady | Predator Room Captain #2 |
| Quentin Mare | Predator Operator Langley #1 |
| Matt Gulbranson | Predator Operator Langley #2 |
| Jill Wolsey | Soccer Mom |
| Annabelle Wallis | Hani's Girlfriend in Bar |
| Kirk Lambert | Special Air Service (uncredited) |
| Kevin L | Dubai Baggage Handler (uncredited) |
